Faculty ProfilesGilad Doitsh, PhD
1001 Potrero Ave
San Francisco, CA 94110
AIDS, Abortive HIV Infection, CD4 T cells, Caspase-1, Cell-to-cell transmission of viruses, HIV, HIV Pathogenesis, HIV accessory proteins (e.g. Vpr, ICAM-1, Inflammation, Innate Immunity, LFA-1, Lymphoid Tissues, Pyroptosis, Sensing of intracellular viral DNA and other pathogen-associated molecular patterns (PAMPS) by pattern recognition receptors (PRRs), Virological synapse, Vpx)Awards and Honors
CFAR Early Career Investigator Award for Excellence in Basic Research., UCSF, 2014-2015
The Gladstone Institute of Virology and Immunology Award for Scientific Excellence, The Gladstone Institutes, UCSF, 2010-2011
Related Web Sites
In the News
- AIDS Researchers Unlock Cell Death Mystery
- Cell-suicide blocker holds promise as HIV therapy
- The Noisy Mass Suicide That Leads to AIDS
Recent Articles (14)
Galloway NL, Doitsh G, Monroe KM, Yang Z, Muñoz-Arias I, Levy DN, Greene WC. Cell-to-Cell Transmission of HIV-1 Is Required to Trigger Pyroptotic Death of Lymphoid-Tissue-Derived CD4 T Cells. Cell Rep. 2015 Sep 8; 12(10):1555-63.
Doitsh G, Galloway NL, Geng X, Yang Z, Monroe KM, Zepeda O, Hunt PW, Hatano H, Sowinski S, Muñoz-Arias I, Greene WC. Cell death by pyroptosis drives CD4 T-cell depletion in HIV-1 infection. Nature. 2014 Jan 23; 505(7484):509-14.
Monroe KM, Yang Z, Johnson JR, Geng X, Doitsh G, Krogan NJ, Greene WC. IFI16 DNA sensor is required for death of lymphoid CD4 T cells abortively infected with HIV. Science. 2014 Jan 24; 343(6169):428-32.
Doitsh G, Cavrois M, Lassen KG, Zepeda O, Yang Z, Santiago ML, Hebbeler AM, Greene WC. Abortive HIV infection mediates CD4 T cell depletion and inflammation in human lymphoid tissue. Cell. 2010 Nov 24; 143(5):789-801.
Ori A, Zauberman A, Doitsh G, Paran N, Oren M, Shaul Y. p53 binds and represses the HBV enhancer: an adjacent enhancer element can reverse the transcription effect of p53. EMBO J. 1998 Jan 15; 17(2):544-53.