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Faculty Profiles

John Mills
M_MED-AIDS-ZSFG
Professor

220 Montgomery St
San Francisco, CA 94104

mills@portsea.net

Education and Training

Location Degree or Training Specialty Date
University of California, San Francisco Residency Internal Medicine

Awards and Honors

2010   Life Membership, Royal Australian College of Physicians, 2010
2010   40 Year Commendation, American Society for Microbiology, 2010
2003   Wunderly Oration & Medal, Royal Australian College of Physicians, 2003
1996   Kincaid Smith Oration and Medal, Royal Australian College of Physicians, 1996
1990   Certificate of Appreciation, USPHS-NIH-NIAID, 1990

Recent Articles (82)

Lo CH, Nottle T, Mills J. Keystone Island Flap: Effects of Islanding on Vascularity. Plast Reconstr Surg Glob Open. 2016 Feb; 4(2):e617.

Gordon CL, Cheng AC, Cameron PU, Bailey M, Crowe SM, Mills J. Quantitative Assessment of Intra-Patient Variation in CD4+ T Cell Counts in Stable, Virologically-Suppressed, HIV-Infected Subjects. PLoS One. 2015; 10(6):e0125248.

Heslop JA, Hammond TG, Santeramo I, Tort Piella A, Hopp I, Zhou J, Baty R, Graziano EI, Proto Marco B, Caron A, Sköld P, Andrews PW, Baxter MA, Hay DC, Hamdam J, Sharpe ME, Patel S, Jones DR, Reinhardt J, Danen EH, Ben-David U, Stacey G, Björquist P, Piner J, Mills J, Rowe C, Pellegrini G, Sethu S, Antoine DJ, Cross MJ, Murray P, Williams DP, Kitteringham NR, Goldring CE, Park BK. Concise review: workshop review: understanding and assessing the risks of stem cell-based therapies. Stem Cells Transl Med. 2015 Apr; 4(4):389-400.

Styles C, Ferris N, Mitchell C, Murphy D, Frydenberg M, Mills J, Pedersen J, Bergen N, Duchesne G. Multiparametric 3T MRI in the evaluation of intraglandular prostate cancer: correlation with histopathology. J Med Imaging Radiat Oncol. 2014 Aug; 58(4):439-48.

Severi G, FitzGerald LM, Muller DC, Pedersen J, Longano A, Southey MC, Hopper JL, English DR, Giles GG, Mills J. A three-protein biomarker panel assessed in diagnostic tissue predicts death from prostate cancer for men with localized disease. Cancer Med. 2014 Oct; 3(5):1266-74.

Duncan A, Mills J. An unusual case of HIV virologic failure during treatment with boosted atazanavir. AIDS. 2013 May 15; 27(8):1361-2.

Parr RL, Mills J, Harbottle A, Creed JM, Crewdson G, Reguly B, Guimont FS. Mitochondria, prostate cancer, and biopsy sampling error. Discov Med. 2013 Apr; 15(83):213-20.

Rezaei SD, Hearps AC, Mills J, Pedersen J, Tachedjian G. No association between XMRV or related gammaretroviruses in Australian prostate cancer patients. Virol J. 2013 Jan 10; 10:20.

Mills J, Oliver A, Sherwin JC, Frydenberg M, Peters JS, Costello A, Harewood L, Love C, Redgrave N, van Golen KL, Bailey M, Pedersen J. Utility of RhoC and ZAG protein expression as biomarkers for prediction of PSA failure following radical prostatectomy for high grade prostate cancer. Pathology. 2012 Oct; 44(6):513-8.

Ghildyal R, Jans DA, Bardin PG, Mills J. Protein-protein interactions in RSV assembly: potential targets for attenuating RSV strains. Infect Disord Drug Targets. 2012 Apr; 12(2):103-9.

Kerger M, Hong MK, Pedersen J, Nottle T, Ryan A, Mills J, Peters JS, Moon D, Crowe H, Costello AJ, Corcoran NM, Hovens CM. Microscopic assessment of fresh prostate tumour specimens yields significantly increased rates of correctly annotated samples for downstream analysis. Pathology. 2012 Apr; 44(3):204-8.

Ghildyal R, Mills J. RSV research is now close to providing solutions to RSV infection. Infect Disord Drug Targets. 2012 Apr; 12(2):91.

Hearps AC, Angelovich TA, Jaworowski A, Mills J, Landay AL, Crowe SM. HIV infection and aging of the innate immune system. Sex Health. 2011 Dec; 8(4):453-64.

Pedersen JS, Clarke I, Mills J. Improved detection of mycobacteria species in formalin-fixed tissue sections. Histopathology. 2011 Nov; 59(5):993-1005.

O'Brien BA, Cohen RJ, Ryan A, Sengupta S, Mills J. A new preoperative nomogram to predict minimal prostate cancer: accuracy and error rates compared to other tools to select patients for active surveillance. J Urol. 2011 Nov; 186(5):1811-7.

Sherwin JC, Mirmilstein G, Pedersen J, Lawrentschuk N, Bolton D, Mills J. Tumor volume in radical prostatectomy specimens assessed by digital image analysis software correlates with other prognostic factors. J Urol. 2010 May; 183(5):1808-14.

Mills J. Antiretroviral prophylaxis to reduce breast-milk HIV-1 transmission. N Engl J Med. 2008 Oct 23; 359(17):1846; author reply 1846-7.

Li D, Jans DA, Bardin PG, Meanger J, Mills J, Ghildyal R. Association of respiratory syncytial virus M protein with viral nucleocapsids is mediated by the M2-1 protein. J Virol. 2008 Sep; 82(17):8863-70.

Cherry CL, Hoy JF, Rowe JS, Krum H, Mills J, Lewin SR. Phase 1 single dose studies to optimize the pharmacokinetics of DG17, a novel HIV-protease inhibitor pro-drug, using sodium bicarbonate and ritonavir. Curr HIV Res. 2008 May; 6(3):272-5.

Gorry PR, McPhee DA, Verity E, Dyer WB, Wesselingh SL, Learmont J, Sullivan JS, Roche M, Zaunders JJ, Gabuzda D, Crowe SM, Mills J, Lewin SR, Brew BJ, Cunningham AL, Churchill MJ. Pathogenicity and immunogenicity of attenuated, nef-deleted HIV-1 strains in vivo. Retrovirology. 2007 Sep 23; 4:66.

Azzam R, Lal L, Goh SL, Kedzierska K, Jaworowski A, Naim E, Cherry CL, Wesselingh SL, Mills J, Crowe SM. Adverse effects of antiretroviral drugs on HIV-1-infected and -uninfected human monocyte-derived macrophages. J Acquir Immune Defic Syndr. 2006 May; 42(1):19-28.

Gonzales M, Dale S, Susman M, Mills J. Quantitation of chromosome 1p and 19q deletions in glial tumours by interphase FISH on formalin-fixed paraffin-embedded tissue. J Clin Neurosci. 2006 Jan; 13(1):96-101.

Ghildyal R, Li D, Peroulis I, Shields B, Bardin PG, Teng MN, Collins PL, Meanger J, Mills J. Interaction between the respiratory syncytial virus G glycoprotein cytoplasmic domain and the matrix protein. J Gen Virol. 2005 Jul; 86(Pt 7):1879-84.

Crowe SM, Ho DD, Marriott D, Brew B, Gorry PR, Sullivan JS, Learmont J, Mills J. In vivo replication kinetics of a nef-deleted strain of HIV-1. AIDS. 2005 May 20; 19(8):842-3.

Churchill M, Sterjovski J, Gray L, Cowley D, Chatfield C, Learmont J, Sullivan JS, Crowe SM, Mills J, Brew BJ, Wesselingh SL, McPhee DA, Gorry PR. Longitudinal analysis of nef/long terminal repeat-deleted HIV-1 in blood and cerebrospinal fluid of a long-term survivor who developed HIV-associated dementia. J Infect Dis. 2004 Dec 15; 190(12):2181-6.

Latiff K, Meanger J, Mills J, Ghildyal R. Sequence and structure relatedness of matrix protein of human respiratory syncytial virus with matrix proteins of other negative-sense RNA viruses. Clin Microbiol Infect. 2004 Oct; 10(10):945-8.

Shields B, Mills J, Ghildyal R, Gooley P, Meanger J. Multiple heparin binding domains of respiratory syncytial virus G mediate binding to mammalian cells. Arch Virol. 2003 Oct; 148(10):1987-2003.

Marty A, Meanger J, Mills J, Shields B, Ghildyal R. Association of matrix protein of respiratory syncytial virus with the host cell membrane of infected cells. Arch Virol. 2004 Jan; 149(1):199-210.

Ghildyal R, Baulch-Brown C, Mills J, Meanger J. The matrix protein of Human respiratory syncytial virus localises to the nucleus of infected cells and inhibits transcription. Arch Virol. 2003 Jul; 148(7):1419-29.

Blower S, Schwartz EJ, Mills J. Forecasting the future of HIV epidemics: the impact of antiretroviral therapies & imperfect vaccines. AIDS Rev. 2003 Apr-Jun; 5(2):113-25.

Ison MG, Mills J, Openshaw P, Zambon M, Osterhaus A, Hayden F. Current research on respiratory viral infections: Fourth International Symposium. Antiviral Res. 2002 Aug; 55(2):227-78.

Jekle A, Schramm B, Jayakumar P, Trautner V, Schols D, De Clercq E, Mills J, Crowe SM, Goldsmith MA. Coreceptor phenotype of natural human immunodeficiency virus with nef deleted evolves in vivo, leading to increased virulence. J Virol. 2002 Jul; 76(14):6966-73.

Ghildyal R, Mills J, Murray M, Vardaxis N, Meanger J. Respiratory syncytial virus matrix protein associates with nucleocapsids in infected cells. J Gen Virol. 2002 Apr; 83(Pt 4):753-7.

Greenway AL, McPhee DA, Allen K, Johnstone R, Holloway G, Mills J, Azad A, Sankovich S, Lambert P. Human immunodeficiency virus type 1 Nef binds to tumor suppressor p53 and protects cells against p53-mediated apoptosis. J Virol. 2002 Mar; 76(6):2692-702.

Birch MR, Learmont JC, Dyer WB, Deacon NJ, Zaunders JJ, Saksena N, Cunningham AL, Mills J, Sullivan JS. An examination of signs of disease progression in survivors of the Sydney Blood Bank Cohort (SBBC). J Clin Virol. 2001 Oct; 22(3):263-70.

Vandegraaff N, Kumar R, Hocking H, Burke TR, Mills J, Rhodes D, Burrell CJ, Li P. Specific inhibition of human immunodeficiency virus type 1 (HIV-1) integration in cell culture: putative inhibitors of HIV-1 integrase. Antimicrob Agents Chemother. 2001 Sep; 45(9):2510-6.

Dunne AL, Mitchell FM, Coberly SK, Hellmann NS, Hoy J, Mijch A, Petropoulos CJ, Mills J, Crowe SM. Comparison of genotyping and phenotyping methods for determining susceptibility of HIV-1 to antiretroviral drugs. AIDS. 2001 Aug 17; 15(12):1471-5.

Schmidt AC, Couch RB, Galasso GJ, Hayden FG, Mills J, Murphy BR, Chanock RM. Current research on respiratory viral infections: Third International Symposium. Antiviral Res. 2001 Jun; 50(3):157-96.

Kedzierska K, Mak J, Jaworowski A, Greenway A, Violo A, Chan HT, Hocking J, Purcell D, Sullivan JS, Mills J, Crowe S. nef-deleted HIV-1 inhibits phagocytosis by monocyte-derived macrophages in vitro but not by peripheral blood monocytes in vivo. AIDS. 2001 May 25; 15(8):945-55.

Blower SM, Koelle K, Kirschner DE, Mills J. Live attenuated HIV vaccines: predicting the tradeoff between efficacy and safety. Proc Natl Acad Sci U S A. 2001 Mar 13; 98(6):3618-23.

Purcell DF, Cameron PU, Mills J, Kent S. Infectivity of wild-type and deleted proviral SIV DNA. Dev Biol (Basel). 2001; 106:395-406.

Mills J, Desrosiers R, Rud E, Almond N. Live attenuated HIV vaccines: a proposal for further research and development. AIDS Res Hum Retroviruses. 2000 Oct 10; 16(15):1453-61.

Ghildyal R, Hartley C, Varrasso A, Meanger J, Voelker DR, Anders EM, Mills J. Surfactant protein A binds to the fusion glycoprotein of respiratory syncytial virus and neutralizes virion infectivity. J Infect Dis. 1999 Dec; 180(6):2009-13.

Learmont JC, Geczy AF, Mills J, Ashton LJ, Raynes-Greenow CH, Garsia RJ, Dyer WB, McIntyre L, Oelrichs RB, Rhodes DI, Deacon NJ, Sullivan JS. Immunologic and virologic status after 14 to 18 years of infection with an attenuated strain of HIV-1. A report from the Sydney Blood Bank Cohort. N Engl J Med. 1999 Jun 03; 340(22):1715-22.

Tachedjian G, French M, Mills J. Coresistance to zidovudine and foscarnet is associated with multiple mutations in the human immunodeficiency virus type 1 reverse transcriptase. Antimicrob Agents Chemother. 1998 Nov; 42(11):3038-43.

Tachedjian G, Mellors JW, Bazmi H, Mills J. Impaired fitness of foscarnet-resistant strains of human immunodeficiency virus type 1. AIDS Res Hum Retroviruses. 1998 Aug 10; 14(12):1059-64.

Lewin SR, Kirihara J, Sonza S, Irving L, Mills J, Crowe SM. HIV-1 DNA and mRNA concentrations are similar in peripheral blood monocytes and alveolar macrophages in HIV-1-infected individuals. AIDS. 1998 May 07; 12(7):719-27.

Greenway AL, Mills J, Rhodes D, Deacon NJ, McPhee DA. Serological detection of attenuated HIV-1 variants with nef gene deletions. AIDS. 1998 Apr 16; 12(6):555-61.

Gorman JJ, Ferguson BL, Speelman D, Mills J. Determination of the disulfide bond arrangement of human respiratory syncytial virus attachment (G) protein by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. Protein Sci. 1997 Jun; 6(6):1308-15.

Lewin SR, Lambert P, Deacon NJ, Mills J, Crowe SM. Constitutive expression of p50 homodimer in freshly isolated human monocytes decreases with in vitro and in vivo differentiation: a possible mechanism influencing human immunodeficiency virus replication in monocytes and mature macrophages. J Virol. 1997 Mar; 71(3):2114-9.

Ghildyal R, Hogg G, Mills J, Meanger J. Detection and subgrouping of respiratory syncytial virus directly from nasopharyngeal aspirates. Clin Microbiol Infect. 1997 Feb; 3(1):120-123.

Tachedjian G, Mellors J, Bazmi H, Birch C, Mills J. Zidovudine resistance is suppressed by mutations conferring resistance of human immunodeficiency virus type 1 to foscarnet. J Virol. 1996 Oct; 70(10):7171-81.

Greenway A, Azad A, Mills J, McPhee D. Human immunodeficiency virus type 1 Nef binds directly to Lck and mitogen-activated protein kinase, inhibiting kinase activity. J Virol. 1996 Oct; 70(10):6701-8.

Hartley CA, Gilbert MJ, Brigido L, Elbeik T, Levy JA, Crowe SM, Mills J. Human immunodeficiency virus grown in CD4-expressing cells is associated with CD4. J Gen Virol. 1996 Sep; 77 ( Pt 9):2015-23.

Lewin SR, Sonza S, Irving LB, McDonald CF, Mills J, Crowe SM. Surface CD4 is critical to in vitro HIV infection of human alveolar macrophages. AIDS Res Hum Retroviruses. 1996 Jul 01; 12(10):877-83.

Sonza S, Maerz A, Deacon N, Meanger J, Mills J, Crowe S. Human immunodeficiency virus type 1 replication is blocked prior to reverse transcription and integration in freshly isolated peripheral blood monocytes. J Virol. 1996 Jun; 70(6):3863-9.

Deacon NJ, McPhee DA, Crowe S, Learmont J, Mills J. Response: Attenuated HIV Vaccine: Caveats. Science. 1996 Mar 29; 271(5257):1791-2.

Deacon NJ, Tsykin A, Solomon A, Smith K, Ludford-Menting M, Hooker DJ, McPhee DA, Greenway AL, Ellett A, Chatfield C, Lawson VA, Crowe S, Maerz A, Sonza S, Learmont J, Sullivan JS, Cunningham A, Dwyer D, Dowton D, Mills J. Genomic structure of an attenuated quasi species of HIV-1 from a blood transfusion donor and recipients. Science. 1995 Nov 10; 270(5238):988-91.

Tachedjian G, Hooker DJ, Gurusinghe AD, Bazmi H, Deacon NJ, Mellors J, Birch C, Mills J. Characterisation of foscarnet-resistant strains of human immunodeficiency virus type 1. Virology. 1995 Sep 10; 212(1):58-68.

Crowe SM, Vardaxis NJ, Kent SJ, Maerz AL, Hewish MJ, McGrath MS, Mills J. HIV infection of monocyte-derived macrophages in vitro reduces phagocytosis of Candida albicans. J Leukoc Biol. 1994 Sep; 56(3):318-27.

Dunne AL, Siregar H, Mills J, Crowe SM. HIV replication in chronically infected macrophages is not inhibited by the Tat inhibitors Ro-5-3335 and Ro-24-7429. J Leukoc Biol. 1994 Sep; 56(3):369-73.

Safrin S, Elbeik T, Phan L, Robinson D, Rush J, Elbaggari A, Mills J. Correlation between response to acyclovir and foscarnet therapy and in vitro susceptibility result for isolates of herpes simplex virus from human immunodeficiency virus-infected patients. Antimicrob Agents Chemother. 1994 Jun; 38(6):1246-50.

Crowe SM, Mills J, Elbeik T, Lifson JD, Kosek J, Marshall JA, Engleman EG, McGrath MS. Human immunodeficiency virus-infected monocyte-derived macrophages express surface gp120 and fuse with CD4 lymphoid cells in vitro: a possible mechanism of T lymphocyte depletion in vivo. Clin Immunol Immunopathol. 1992 Nov; 65(2):143-51.

Crowe SM, Elbeik T, Ulrich PP, Mills J, Moss A. Lack of evidence of occult human immunodeficiency virus in seronegative individuals at very high risk of infection. J Med Virol. 1991 Nov; 35(3):160-4.

Safrin S, Ashley R, Houlihan C, Cusick PS, Mills J. Clinical and serologic features of herpes simplex virus infection in patients with AIDS. AIDS. 1991 Sep; 5(9):1107-10.

Kaplan LD, Kahn JO, Crowe S, Northfelt D, Neville P, Grossberg H, Abrams DI, Tracey J, Mills J, Volberding PA. Clinical and virologic effects of recombinant human granulocyte-macrophage colony-stimulating factor in patients receiving chemotherapy for human immunodeficiency virus-associated non-Hodgkin's lymphoma: results of a randomized trial. J Clin Oncol. 1991 Jun; 9(6):929-40.

Weiler BE, Schäcke H, Bachmann M, Brigido L, Gilbert M, Mills J, Matthes E, Forrest JM, Müller WE. Human immunodeficiency virus: novel enzyme-linked immunoassays for quantitation of envelope glycoprotein 120. J Virol Methods. 1991 May; 32(2-3):287-301.

Crowe S, Mills J, McGrath MS. Mediators of fusion between HIV-infected macrophages and lymphoid cells. Adv Exp Med Biol. 1991; 300:57-66; discussion 67-9.

Gilbert M, Kirihara J, Mills J. Enzyme-linked immunoassay for human immunodeficiency virus type 1 envelope glycoprotein 120. J Clin Microbiol. 1991 Jan; 29(1):142-7.

Crowe SM, Mills J, Kirihara J, Boothman J, Marshall JA, McGrath MS. Full-length recombinant CD4 and recombinant gp120 inhibit fusion between HIV infected macrophages and uninfected CD4-expressing T-lymphoblastoid cells. AIDS Res Hum Retroviruses. 1990 Aug; 6(8):1031-7.

Safrin S, Rush JD, Mills J. Influenza in patients with human immunodeficiency virus infection. Chest. 1990 Jul; 98(1):33-7.

Crowe SM, McGrath MS, Elbeik T, Kirihara J, Mills J. Comparative assessment of antiretrovirals in human monocyte-macrophages and lymphoid cell lines acutely and chronically infected with the human immunodeficiency virus. J Med Virol. 1989 Nov; 29(3):176-80.

Ng VL, Chiang CS, Debouck C, McGrath MS, Grove TH, Mills J. Reliable confirmation of antibodies to human immunodeficiency virus type 1 (HIV-1) with an enzyme-linked immunoassay using recombinant antigens derived from the HIV-1 gag, pol, and env genes. J Clin Microbiol. 1989 May; 27(5):977-82.

Locksley RM, Crowe S, Sadick MD, Heinzel FP, Gardner KD, McGrath MS, Mills J. Release of interleukin 1 inhibitory activity (contra-IL-1) by human monocyte-derived macrophages infected with human immunodeficiency virus in vitro and in vivo. J Clin Invest. 1988 Dec; 82(6):2097-105.

Jacobson MA, Crowe S, Levy J, Aweeka F, Gambertoglio J, McManus N, Mills J. Effect of Foscarnet therapy on infection with human immunodeficiency virus in patients with AIDS. J Infect Dis. 1988 Oct; 158(4):862-5.

Crowe S, Mills J, McGrath MS. Quantitative immunocytofluorographic analysis of CD4 surface antigen expression and HIV infection of human peripheral blood monocyte/macrophages. AIDS Res Hum Retroviruses. 1987; 3(2):135-45.

Mills M, Wofsy CB, Mills J. The acquired immunodeficiency syndrome. Infection control and public health law. N Engl J Med. 1986 Apr 03; 314(14):931-6.

Levy JA, Shimabukuro J, Hollander H, Mills J, Kaminsky L. Isolation of AIDS-associated retroviruses from cerebrospinal fluid and brain of patients with neurological symptoms. Lancet. 1985 Sep 14; 2(8455):586-8.

Mills J, Van Kirk JE, Wright PF, Chanock RM. Experimental respiratory syncytial virus infection of adults. Possible mechanisms of resistance to infection and illness. J Immunol. 1971 Jul; 107(1):123-30.

Chanock RM, Kapikian AZ, Mills J, Kim HW, Parrott RH. Influence of immunological factors in respiratory syncytial virus disease. Arch Environ Health. 1970 Sep; 21(3):347-55.

Kim HW, Bellanti JA, Arrobio JO, Mills J, Brandt CD, Chanock RM, Parrott RH. Respiratory syncytial virus neutralizing activity in nasal secretions following natural infection. Proc Soc Exp Biol Med. 1969 Jun; 131(2):658-61.

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